Field evidence of Trypanosoma cruzi infection, diverse host use and invasion of human dwellings by the Chagas disease vector in Florida, USA
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F25%3A43909843" target="_blank" >RIV/60076658:12310/25:43909843 - isvavai.cz</a>
Result on the web
<a href="https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0012920" target="_blank" >https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0012920</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pntd.0012920" target="_blank" >10.1371/journal.pntd.0012920</a>
Alternative languages
Result language
angličtina
Original language name
Field evidence of Trypanosoma cruzi infection, diverse host use and invasion of human dwellings by the Chagas disease vector in Florida, USA
Original language description
Background Triatomine bugs (Hemiptera, Reduviidae, Triatominae) are blood-sucking vectors of the protozoan parasite, Trypanosoma cruzi, which causes Chagas disease, a significant source of human morbidity and mortality in the Americas. Autochthonous transmission of Chagas disease in the United States is considered rare, despite evidence of Triatoma species harboring T. cruzi, invading homes, and biting occupants. In the southeastern United States, Triatoma sanguisuga is considered common, yet its distribution, host use, and T. cruzi infection are practically unknown in this region.Methodology/Principle findings Using field sampling and community science programs from 2013 to 2023, we collected triatomines from peridomestic and domestic settings, identified them to species, analyzed for bloodmeals, and screened for T. cruzi infection and Discrete Typing Units (DTUs) TcI - TcVI utilizing molecular techniques. Triatoma sanguisuga (n = 310) were collected from 23 counties throughout the state, particularly in northern and central Florida. More than one third (34.6%) of T. sanguisuga were found inside a human dwelling, and 39.2% were collected by community members. T. cruzi infection was observed in 29.5% (88/298) of tested triatomines, with infection found in 12 of the 23 counties where triatomines had been collected. DTU-typing was successful for 47 of the T. cruzi-positive triatomines: 74.5% were infected with DTU TcI, 21.3% were infected with DTU TcIV, and 4.3% were co-infected with TcI and TcIV. Bloodmeal analysis of 144 T. sanguisuga found broad host use, including mammals (60%), ectothermic vertebrates (37%), and cockroaches (2.5%). Human blood meals contributed nearly a quarter (23%) of bloodmeals, indicating significant vector-human contact.Conclusion/Significance Our field data from Florida demonstrate that T. sanguisuga is present near, and sometimes in, human dwellings, feeds upon humans, and is infected with multiple DTUs of T. cruzi. This indicates that the environment in the southeastern United States is suitable for autochthonous transmission of Chagas disease or that the human risk for T. cruzi infection is possible. The roles of ectotherms in T. sanguisuga and T. cruzi ecology also warrant further investigation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
<a href="/en/project/GM21-10185M" target="_blank" >GM21-10185M: Vectors, symbionts and pathogens: a complex story of Triatominae microbiomes</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS Neglected Tropical Diseases
ISSN
1935-2735
e-ISSN
1935-2735
Volume of the periodical
19
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
20
Pages from-to
nestránkováno
UT code for WoS article
001524169700007
EID of the result in the Scopus database
2-s2.0-105010782017