Characterization of Guinea Pig Antibody Responses to Salivary Proteins of Triatoma infestans for the Development of a Triatomine Exposure Marker

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F14%3A00429374" target="_blank" >RIV/60077344:_____/14:00429374 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/14:43887402

Result on the web

<a href="http://dx.doi.org/10.1371/journal.pntd.0002783" target="_blank" >http://dx.doi.org/10.1371/journal.pntd.0002783</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pntd.0002783" target="_blank" >10.1371/journal.pntd.0002783</a>

Result language

angličtina

Original language name

Characterization of Guinea Pig Antibody Responses to Salivary Proteins of Triatoma infestans for the Development of a Triatomine Exposure Marker

Original language description

Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, and currently affects approximately 8 million people in Latin American countries. Although vector control campaigns against the most effective Chagas disease vector, Triatoma infestans, have been highly successful, T. infestans is re-establishing in once-endemic regions. To monitor re-establishing triatomines, new epidemiological tools are needed. Antibody responses of hosts to triatomine salivary proteins represent a promising tool to detect biting bugs, and highly immunogenic salivary antigens may be used as markers of triatomine exposure. Therefore, we analyzed the antibody response of guinea pigs, common peridomestic hosts of T. infestans, to salivary proteins of nymphs and adults of four different T. infestans strains from Argentina, Bolivia, Chile and Peru. Developmental stage- and strain-specific proteins in the saliva of T. infestans influenced the antibody response of guinea pigs, and different salivary anti

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS Neglected Tropical Diseases

ISSN

1935-2735

e-ISSN

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Volume of the periodical

8

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

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UT code for WoS article

000335342400047

EID of the result in the Scopus database

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