Tissue-specific bioconcentration of antidepressants in fish exposed to effluent from a municipal sewage treatment plant

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F14%3A43886844" target="_blank" >RIV/60076658:12520/14:43886844 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0048969714005622" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0048969714005622</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.scitotenv2014.04.052" target="_blank" >10.1016/j.scitotenv2014.04.052</a>

Result language
angličtina
Original language name
Tissue-specific bioconcentration of antidepressants in fish exposed to effluent from a municipal sewage treatment plant
Original language description
Tissue-specific bioconcentration of selected antidepressants was studied in rainbow trout (Oncorhynchus mykiss) exposed to undiluted effluent from a Swedish municipal sewage treatment plant for 13 days. Citalopram, sertraline and venlafaxine were found in the brains and livers of most fish, but not in blood plasma or muscle. Venlafaxine was the only drug found in plasma (3/20 fish). Fluoxetine was not detected in any fish tissue, in accordance with a low concentration in the effluent and a comparably high limit of quantification in tissues. Concentrations of citalopram, sertraline and venlafaxine in fish brain were up to 1/12, 1/8 and 1/26, respectively, of the lowest concentrations found in the brains of mammals treated with therapeutic doses. Thus, given coexposure to several antidepressants and an assumed similar potency in fish, the margin of safety for targetrelated effects in fish residing in effluent-dominated streams is relatively low. Furthermore, the non-detectable levels of
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
DJ - Pollution and water control
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)