Genetic variants in MYF5 affected growth traits and beef quality traits in Chinese Qinchuan cattle
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F20%3A43900908" target="_blank" >RIV/60076658:12520/20:43900908 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.ygeno.2020.03.018" target="_blank" >https://doi.org/10.1016/j.ygeno.2020.03.018</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ygeno.2020.03.018" target="_blank" >10.1016/j.ygeno.2020.03.018</a>
Alternative languages
Result language
angličtina
Original language name
Genetic variants in MYF5 affected growth traits and beef quality traits in Chinese Qinchuan cattle
Original language description
Myogenic factor 5 plays actively roles in the regulation of myogenesis. The aims of this study are to identify the evolution information of MYF5 protein among 10 domestic and mammalian animals, to uncover the expression patterns of MYF5 gene in calves and adults of Qinchuan cattle, and to expose the genetic variants of the MYF5 gene and explore its effect on cattle growth traits and beef quality traits in Qinchuan cattle. The bioinformatics results showed that the MYF5 proteins highly conserved in different mammalian or domestic animals apart from chicken. The expression level of MYF5 gene in the heart, muscle, lung, large intestine and liver was greater than that of other tissues. PCR amplicons sequencing identified four novel SNPs at g.5738A > G, g.5785C > T and g.5816A > G in the 3rd exon region and g.6535A > G in the 3' UTR. Genotypic frequencies of g.5785C > T was harshly deviated from the HWE (P < .05). Genetic diversity was low or intermediate for the four SNPs and those SNPs were in the weak linkage disequilibrium. Association analysis results indicated g.5785C > T, g.5816A > G and g.6535A > G significant effect on growth performance and beef quality traits of Qinchuan cattle. H1H3 diplotype had greater body size and better beef quality. All the results implicate that the MYF5 gene might be applied as a promising candidate gene in Qinchuan cattle breeding.
Czech name
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Czech description
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Classification
Type
J<sub>ost</sub> - Miscellaneous article in a specialist periodical
CEP classification
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OECD FORD branch
40402 - GM technology (crops and livestock), livestock cloning, marker assisted selection, diagnostics (DNA chips and biosensing devices for the early/accurate detection of diseases) biomass feedstock production technologies, biopharming
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
GENOMICS
ISSN
0888-7543
e-ISSN
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Volume of the periodical
112
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
2804-2812
UT code for WoS article
000534479700015
EID of the result in the Scopus database
2-s2.0-85082526743