Evolution of the haem synthetic pathway in kinetoplastid flagellates: An essential pathway that is not essential after all?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F10%3A00342950" target="_blank" >RIV/60077344:_____/10:00342950 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/10:00011901

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Evolution of the haem synthetic pathway in kinetoplastid flagellates: An essential pathway that is not essential after all?

Original language description

Kinetoplastid flagellates represent an interesting group of species, as some of them lost the complete pathway of haem synthesis while others possess only the last 3 biosynthetic steps. We decided to supplement a Current view on the phylogeny of these important pathogens with the expected state of haem synthesis in representative species. We propose a scenario in which the ancestor of all trypanosomatids was completely deficient of the synthesis of haem. In trypanosomatids other than members of the genus Trypanosoma, the pathway was partially rescued by genes encoding enzymes for the last three steps, Supposedly obtained by horizontal transfer from a gamma-proteobacterium. This event preceded the diversification of the non-Trypanosoma trypanosomatids.Later, some flagellates acquired a beta-proteobacterial endosymbiont which supplied them with haem precursors. The medically important trypanosomes have remained fully deficient of haem synthesis and obtain this compound from the host.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal for Parasitology

ISSN

0020-7519

e-ISSN

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Volume of the periodical

40

Issue of the periodical within the volume

2

Country of publishing house

AU - AUSTRALIA

Number of pages

8

Pages from-to

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UT code for WoS article

000274447900002

EID of the result in the Scopus database

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