The convoluted history of haem biosynthesis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F22%3A00555913" target="_blank" >RIV/60077344:_____/22:00555913 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/22:43904672
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1111/brv.12794" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/brv.12794</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/brv.12794" target="_blank" >10.1111/brv.12794</a>
Alternative languages
Result language
angličtina
Original language name
The convoluted history of haem biosynthesis
Original language description
The capacity of haem to transfer electrons, bind diatomic gases, and catalyse various biochemical reactions makes it one of the essential biomolecules on Earth and one that was likely used by the earliest forms of cellular life. Since the description of haem biosynthesis, our understanding of this multi-step pathway has been almost exclusively derived from a handful of model organisms from narrow taxonomic contexts. Recent advances in genome sequencing and functional studies of diverse and previously neglected groups have led to discoveries of alternative routes of haem biosynthesis that deviate from the 'classical' pathway. In this review, we take an evolutionarily broad approach to illuminate the remarkable diversity and adaptability of haem synthesis, from prokaryotes to eukaryotes, showing the range of strategies that organisms employ to obtain and utilise haem. In particular, the complex evolutionary histories of eukaryotes that involve multiple endosymbioses and horizontal gene transfers are reflected in the mosaic origin of numerous metabolic pathways with haem biosynthesis being a striking case. We show how different evolutionary trajectories and distinct life strategies resulted in pronounced tensions and differences in the spatial organisation of the haem biosynthesis pathway, in some cases leading to a complete loss of a haem-synthesis capacity and, rarely, even loss of a requirement for haem altogether.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biological Reviews
ISSN
1464-7931
e-ISSN
1469-185X
Volume of the periodical
97
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
22
Pages from-to
141-162
UT code for WoS article
000693198800001
EID of the result in the Scopus database
2-s2.0-85114355654