Ixodes ricinus tick saliva modulates tick-borne encephalitis virus infection of dendritic cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F10%3A00347290" target="_blank" >RIV/60077344:_____/10:00347290 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/10:00347290
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Ixodes ricinus tick saliva modulates tick-borne encephalitis virus infection of dendritic cells
Original language description
Tick-borne encephalitis virus is an important human pathogen, naturally delivered into host skin via a tick bite. To examine the effects of the virus on dendritic cell biology, we cultured dendritic cells with two tick-borne encephalitis virus strains ofdifferent virulence in the presence of Ixodes ricinus tick saliva. Tick saliva treatment increased proportion of virus-infected cells, led to a decrease in virus-induced TNF-alpha and IL-6 production and to reduced virus-induced apoptosis. Our data indicate that tick saliva modulate virus-mediated alterations in dendritic cells, thus probably being involved in the early infection process in the host.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
—

Project
<a href="/en/project/IAA600960811" target="_blank" >IAA600960811: Identification of tick salivary molecules facilitating transmission of Borrelia burgdorferi using RNA interference</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)