Futile import of tRNAs and proteins into the mitochondrion of Trypanosoma brucei evansi
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F11%3A00359409" target="_blank" >RIV/60077344:_____/11:00359409 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/11:43877694
Result on the web
<a href="http://dx.doi.org/10.1016/j.molbiopara.2010.12.010" target="_blank" >http://dx.doi.org/10.1016/j.molbiopara.2010.12.010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.molbiopara.2010.12.010" target="_blank" >10.1016/j.molbiopara.2010.12.010</a>
Alternative languages
Result language
angličtina
Original language name
Futile import of tRNAs and proteins into the mitochondrion of Trypanosoma brucei evansi
Original language description
Trypanosoma brucei brucei has two distinct developmental stages, the procyclic stage in the insect and the bloodstream stage in the mammalian host. The significance of each developmental stage is punctuated by specific changes in metabolism. In the insect, T. b. brucei is strictly dependent on mitochondrial function and thus respiration to generate the bulk of its ATP, whereas in the mammalian host it relies heavily on glycolysis. Peculiarly, akinetoplastic strains of T. b. evansi that lack mitochondrial DNA do exist in the wild and are developmentally locked in the glycolysis-dependent bloodstream stage. Using RNAi we show that two mitochondrion-imported proteins, mitochondrial RNA polymerase and guide RNA associated protein 1, are still imported intothe nucleic acids-lacking organelle of T. b. evansi, making the need for these proteins futile.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular and Biochemical Parasitology
ISSN
0166-6851
e-ISSN
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Volume of the periodical
176
Issue of the periodical within the volume
2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
5
Pages from-to
116-120
UT code for WoS article
000288629800007
EID of the result in the Scopus database
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