Functional characterization of two defensin isoforms of the hard tick Ixodes ricinus

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F11%3A00360134" target="_blank" >RIV/60077344:_____/11:00360134 - isvavai.cz</a>

Alternative codes found

RIV/61388963:_____/11:00360134 RIV/60076658:12310/11:43869823

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Functional characterization of two defensin isoforms of the hard tick Ixodes ricinus

Original language description

The immune system of ticks is stimulated to produce many pharmacologically active molecules during feeding and especially during pathogen invasion. Defensins represent a specific group of antimicrobial compounds with 6 conserved cysteine residues. Two isoforms of the defensin gene (def1 and def2) were identified in the European tick Ixodes ricinus. Expression of both genes was induced in different tick organs by a blood feeding or pathogen injection. Synthetic peptides def1 and def2 were shown to have antimicrobial activitiy against Gram+ bacteria, while Gram- bacteria, yeast, Tick Borne Encephalitis and West Nile Viruses were shown to be insensitive. In addition to antimicrobial activities, the hemolysis effect of def1 and def2 on human erythrocytes was also established. Defensins may play an important role in defence against different pathogens. Moreover this is a first report of a one amino acid substitution in a defensins molecule and its impact on antimicrobial activity.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Parasites Vectors

ISSN

1756-3305

e-ISSN

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Volume of the periodical

4

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

"e63"

UT code for WoS article

000291094400001

EID of the result in the Scopus database

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