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Tribolium castaneum defensins are primarily active against Gram-positive bacteria

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F15%3A00451350" target="_blank" >RIV/60077344:_____/15:00451350 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.jip.2015.10.009" target="_blank" >http://dx.doi.org/10.1016/j.jip.2015.10.009</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.jip.2015.10.009" target="_blank" >10.1016/j.jip.2015.10.009</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Tribolium castaneum defensins are primarily active against Gram-positive bacteria

  • Original language description

    The red flour beetle Tribolium castaneum is a destructive insect pest of stored food and feed products, and a model organism for development, evolutionary biology and immunity. The insect innate immune system includes antimicrobial peptides (AMPs) with awide spectrum of targets including viruses, bacteria, fungi and parasites. Defensins are an evolutionarily-conserved class of AMPs and a potential new source of antimicrobial agents. In this context, we report the antimicrobial activity, phylogenetic and structural properties of three T. castaneum defensins (Def1, Def2 and Def3) and their relevance in the immunity of T. castaneum against bacterial pathogens. All three recombinant defensins showed bactericidal activity against Micrococcus luteus and Bacillus thuringiensis serovar tolworthi, but only Def1 and Def2 showed a bacteriostatic effect against Staphylococcus epidermidis. None of the defensins showed activity against the Gram-negative bacteria Escherichia coli and Pseudomonas ent

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EI - Biotechnology and bionics

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/EE2.3.30.0032" target="_blank" >EE2.3.30.0032: Promotion of post-doctoral positions in the Biology Centre of the Czech Academy of Sciences aimed to build the global competitiveness of the research teams in the Czech Republic</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Invertebrate Pathology

  • ISSN

    0022-2011

  • e-ISSN

  • Volume of the periodical

    132

  • Issue of the periodical within the volume

    NOV 2015

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    208-215

  • UT code for WoS article

    000365630200023

  • EID of the result in the Scopus database