Tribolium castaneum defensins are primarily active against Gram-positive bacteria
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F15%3A00451350" target="_blank" >RIV/60077344:_____/15:00451350 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.jip.2015.10.009" target="_blank" >http://dx.doi.org/10.1016/j.jip.2015.10.009</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jip.2015.10.009" target="_blank" >10.1016/j.jip.2015.10.009</a>
Alternative languages
Result language
angličtina
Original language name
Tribolium castaneum defensins are primarily active against Gram-positive bacteria
Original language description
The red flour beetle Tribolium castaneum is a destructive insect pest of stored food and feed products, and a model organism for development, evolutionary biology and immunity. The insect innate immune system includes antimicrobial peptides (AMPs) with awide spectrum of targets including viruses, bacteria, fungi and parasites. Defensins are an evolutionarily-conserved class of AMPs and a potential new source of antimicrobial agents. In this context, we report the antimicrobial activity, phylogenetic and structural properties of three T. castaneum defensins (Def1, Def2 and Def3) and their relevance in the immunity of T. castaneum against bacterial pathogens. All three recombinant defensins showed bactericidal activity against Micrococcus luteus and Bacillus thuringiensis serovar tolworthi, but only Def1 and Def2 showed a bacteriostatic effect against Staphylococcus epidermidis. None of the defensins showed activity against the Gram-negative bacteria Escherichia coli and Pseudomonas ent
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EI - Biotechnology and bionics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/EE2.3.30.0032" target="_blank" >EE2.3.30.0032: Promotion of post-doctoral positions in the Biology Centre of the Czech Academy of Sciences aimed to build the global competitiveness of the research teams in the Czech Republic</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Invertebrate Pathology
ISSN
0022-2011
e-ISSN
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Volume of the periodical
132
Issue of the periodical within the volume
NOV 2015
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
208-215
UT code for WoS article
000365630200023
EID of the result in the Scopus database
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