Gene fragmentation: a key to mitochondrial genome evolution in Euglenozoa?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F11%3A00364837" target="_blank" >RIV/60077344:_____/11:00364837 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/11:43869820

Result on the web

<a href="http://dx.doi.org/10.1007/s00294-011-0340-8" target="_blank" >http://dx.doi.org/10.1007/s00294-011-0340-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00294-011-0340-8" target="_blank" >10.1007/s00294-011-0340-8</a>

Result language

angličtina

Original language name

Gene fragmentation: a key to mitochondrial genome evolution in Euglenozoa?

Original language description

Gene fragmentation is a striking feature of both euglenid and diplonemid mtDNAs. To rationalize the emergence of these highly divergent mtDNA types and the existence of insertion/deletion RNA editing (in kinetoplastids) and trans-splicing (in diplonemids), we propose that in the mitochondrion of the common evolutionary ancestor of Euglenozoa, small expressed gene fragments promoted a rampant neutral evolutionary pathway. Interactions between small antisense transcripts of these gene fragments and full-length transcripts, assisted by RNA-processing enzymes, permitted the emergence of RNA editing and/or trans-splicing activities, allowing the system to tolerate indel mutations and further gene fragmentation, respectively, and leading to accumulation of additional mutations. In this way, dramatically different mitochondrial genome structures and RNA-processing machineries were able to evolve.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Current Genetics

ISSN

0172-8083

e-ISSN

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Volume of the periodical

57

Issue of the periodical within the volume

4

Country of publishing house

DE - GERMANY

Number of pages

8

Pages from-to

225-232

UT code for WoS article

000292977000001

EID of the result in the Scopus database

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