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Post-transcriptional mending of gene sequences: looking under the hood of mitochondrial gene expression in diplonemids

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F16%3A00468794" target="_blank" >RIV/60077344:_____/16:00468794 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1080/15476286.2016.1240143" target="_blank" >http://dx.doi.org/10.1080/15476286.2016.1240143</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1080/15476286.2016.1240143" target="_blank" >10.1080/15476286.2016.1240143</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Post-transcriptional mending of gene sequences: looking under the hood of mitochondrial gene expression in diplonemids

  • Original language description

    The instructions to make proteins and structural RNAs are laid down in gene sequences. Yet, in certain instances, these primary instructions need to be modified considerably during gene expression, most often at the transcript level. Here we review a case of massive post-transcriptional revisions via trans-splicing and RNA editing, a phenomenon occurring in mitochondria of a recently recognized protist group, the diplonemids. As of now, the various post-transcriptional steps have been cataloged in detail, but how these processes function is still unknown. Since genetic manipulation techniques such as gene replacement and RNA interference have not yet been established for these organisms, alternative strategies have to be deployed. Here, we discuss the experimental and bioinformatics approaches that promise to unravel the molecular machineries of trans-splicing and RNA editing in Diplonema mitochondria.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA15-21974S" target="_blank" >GA15-21974S: Mitochondrial genome-wide studies of RNA-binding proteins in trypanosomes</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    RNA biology

  • ISSN

    1547-6286

  • e-ISSN

  • Volume of the periodical

    13

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    1204-1211

  • UT code for WoS article

    000390670300005

  • EID of the result in the Scopus database

    2-s2.0-85003794187