Post-transcriptional mending of gene sequences: looking under the hood of mitochondrial gene expression in diplonemids
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F16%3A00468794" target="_blank" >RIV/60077344:_____/16:00468794 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1080/15476286.2016.1240143" target="_blank" >http://dx.doi.org/10.1080/15476286.2016.1240143</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/15476286.2016.1240143" target="_blank" >10.1080/15476286.2016.1240143</a>
Alternative languages
Result language
angličtina
Original language name
Post-transcriptional mending of gene sequences: looking under the hood of mitochondrial gene expression in diplonemids
Original language description
The instructions to make proteins and structural RNAs are laid down in gene sequences. Yet, in certain instances, these primary instructions need to be modified considerably during gene expression, most often at the transcript level. Here we review a case of massive post-transcriptional revisions via trans-splicing and RNA editing, a phenomenon occurring in mitochondria of a recently recognized protist group, the diplonemids. As of now, the various post-transcriptional steps have been cataloged in detail, but how these processes function is still unknown. Since genetic manipulation techniques such as gene replacement and RNA interference have not yet been established for these organisms, alternative strategies have to be deployed. Here, we discuss the experimental and bioinformatics approaches that promise to unravel the molecular machineries of trans-splicing and RNA editing in Diplonema mitochondria.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA15-21974S" target="_blank" >GA15-21974S: Mitochondrial genome-wide studies of RNA-binding proteins in trypanosomes</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
RNA biology
ISSN
1547-6286
e-ISSN
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Volume of the periodical
13
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
1204-1211
UT code for WoS article
000390670300005
EID of the result in the Scopus database
2-s2.0-85003794187