Trypanosoma brucei Mitochondrial Respiratome: Composition and Organization in Procyclic Form

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F11%3A00367704" target="_blank" >RIV/60077344:_____/11:00367704 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1074/mcp.M110.006908" target="_blank" >http://dx.doi.org/10.1074/mcp.M110.006908</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1074/mcp.M110.006908" target="_blank" >10.1074/mcp.M110.006908</a>

Result language

angličtina

Original language name

Trypanosoma brucei Mitochondrial Respiratome: Composition and Organization in Procyclic Form

Original language description

The mitochondrial respiratory chain is comprised of four different protein complexes (I-IV), which are responsible for electron transport and generation of proton gradient in the mitochondrial intermembrane space. In this study, the respiratory complexesI, II, and III were affinity purified from Trypanosoma brucei procyclic form cells and their composition was determined by mass spectrometry. The results showed that the respiratome of Trypanosoma is divergent because many of its proteins are unique tothis group of organisms. Proteomics data from analyses of complexes purified using numerous tagged component proteins in each of the five complexes were used to generate the first predicted protein-protein interaction network of the Trypanosoma brucei respiratory chain. These results provide the first comprehensive insight into the unique composition of the respiratory complexes in Trypanosoma brucei, an early diverged eukaryotic pathogen.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/GP204%2F09%2FP563" target="_blank" >GP204/09/P563: Functional analysis of two novel subunits of the F0F1-ATP synthase complex in Trypanosoma brucei</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular and Cellular Proteomics

ISSN

1535-9476

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

14

Pages from-to

1-14

UT code for WoS article

000294729200007

EID of the result in the Scopus database

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