Disparate phenotypic effects from the knockdown of various Trypanosoma brucei cytochrome c oxidase subunits

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F12%3A00377492" target="_blank" >RIV/60077344:_____/12:00377492 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/12:43883429
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0166685112001065#" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0166685112001065#</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.molbiopara.2012.04.013" target="_blank" >10.1016/j.molbiopara.2012.04.013</a>

Result language
angličtina
Original language name
Disparate phenotypic effects from the knockdown of various Trypanosoma brucei cytochrome c oxidase subunits
Original language description
The Trypanosoma brucei cytochrome c oxidase (respiratory complex IV) is a very divergent complex containing a surprisingly high number of trypanosomatid-specific subunits with unknown function. To gain insight into the functional organization of this large protein complex, the expression of three novel subunits were down-regulated by RNA interference. We demonstrated that all three subunits were important for the structural integrity of the cytochrome c oxidase complex and their knockdowns caused severephenotypes related to mitochondrial functions. Surprisingly, these subunits produced a disparate effect regarding the activity of the neighboring complex III and ROS production. These results suggest that all three subunits are genuine subunits of T. brucei complex IV, though they may have different functional roles, perhaps involving the ability to communicate between sequential enzymes in the respiratory chain.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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