Trypanosoma brucei solanesyl-diphosphate synthase localizes to the mitochondrion

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F12%3A00377250" target="_blank" >RIV/60077344:_____/12:00377250 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/12:43883297
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0166685112000539" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0166685112000539</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.molbiopara.2012.02.011" target="_blank" >10.1016/j.molbiopara.2012.02.011</a>

Result language
angličtina
Original language name
Trypanosoma brucei solanesyl-diphosphate synthase localizes to the mitochondrion
Original language description
Polyprenyl-diphosphate synthase is a key enzyme in the biosynthesis of ubiquinone, a molecule considered essential for a typical eukaryotic cell. Its orthologue in the American stercorarian flagellate Trypanosoma cruzi, solanesyl diphosphate synthase, has been previously localized into the glycosomes. We wondered whether this unique cellular localization is shared by other trypanosome species. Using digitonin permeabilization, immunofluorescence and in situ tagging techniques, we show that in Trypanosoma brucei, the African salivarian flagellate, the enzyme localizes to the mitochondrion.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—

Project
<a href="/en/project/GAP305%2F11%2F2179" target="_blank" >GAP305/11/2179: Characterization of Fe-S cluster assembly in Trypanosoma brucei</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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