Transport, metabolism, cytotoxicity and effects of novel taxanes on the cell cycle in MDA-MB-435 and NCI/ADR-RES cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F12%3A00380490" target="_blank" >RIV/60077344:_____/12:00380490 - isvavai.cz</a>
Alternative codes found
RIV/67985807:_____/12:00380490 RIV/00216208:11120/12:43902770 RIV/75010330:_____/12:00009721
Result on the web
<a href="http://dx.doi.org/10.1007/s00210-012-0785-4" target="_blank" >http://dx.doi.org/10.1007/s00210-012-0785-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00210-012-0785-4" target="_blank" >10.1007/s00210-012-0785-4</a>
Alternative languages
Result language
angličtina
Original language name
Transport, metabolism, cytotoxicity and effects of novel taxanes on the cell cycle in MDA-MB-435 and NCI/ADR-RES cells
Original language description
Resistance of tumours to taxanes causes chemotherapy failure in numerous patients. Resistance is partly due to the low tumour uptake of taxanes and their rapid metabolism. Structural modifications of taxanes can reduce their P-glycoprotein-related effluxor decrease metabolism and consequently increase taxane efficiency. This study compared cytotoxicity and effects of the cell cycle, transport and metabolism of novel taxanes SB-T-1102, SB-T-1103, SB-T-1214 and SB-T-1216, fluorinated SB-T-12851, SB-T-12852, SB-T-12853, SB-T-12854 and IDN5109 with paclitaxel in paclitaxel-sensitive (MDA-MB-435) and paclitaxel-resistant (NCI/ADR-RES) human cancer cells. We have shown before that NCI/ADR-RES cells were 1,000-fold less sensitive to paclitaxel than MDA-MB-435 cells in correspondence to P-glycoprotein overexpression and up to 20-fold lower uptake of the drug in the resistant cells. The uptake of novel taxanes was 1.2 to 3.8 times lower than that of paclitaxel in the MDA-MB-435 cells, but 1.5
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Naunyn-Schmiedeberg's Archiv of Pharmacology
ISSN
0028-1298
e-ISSN
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Volume of the periodical
385
Issue of the periodical within the volume
10
Country of publishing house
DE - GERMANY
Number of pages
14
Pages from-to
1035-1048
UT code for WoS article
000308545300010
EID of the result in the Scopus database
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