Processing of superparamagnetic iron contrast agent ferucarbotran in transplanted pancreatic islets
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F12%3A00386218" target="_blank" >RIV/60077344:_____/12:00386218 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/12:00055971
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/cmmi.1477/full" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/cmmi.1477/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cmmi.1477" target="_blank" >10.1002/cmmi.1477</a>
Alternative languages
Result language
angličtina
Original language name
Processing of superparamagnetic iron contrast agent ferucarbotran in transplanted pancreatic islets
Original language description
Labeling of pancreatic islets with superparamagnetic iron oxide (SPIO) nanoparticles enables their post-transplant monitoring by magnetic resonance imaging (MRI). Although the nanoparticles are incorporated into islet cells in culture, little is known about their fate in vivo. We studied the morphology of labeled islets after transplantation, aiming to identify the MRI contrast particles and their relationship to transplantation outcomes. Rat islets labeled with the ferucarbotran were transplanted intothe liver or under the kidney capsule of syngeneic and allogeneic rats. After in vivo MRI, morphology was studied by light, fluorescence and transmission electron microscopy. Morphology of syngeneic islets transplanted beneath the kidney capsule vs intothe liver was similar. Iron particles were almost completely eliminated from the endocrine cells and remained located in host-derived macrophages surrounding the vital islets for the entire study period. In the allogeneic model, islets lo
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Contrast Media & Molecular Imaging
ISSN
1555-4309
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
6
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
485-493
UT code for WoS article
000308940900002
EID of the result in the Scopus database
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