Functional characterization of two paralogs that are novel RNA binding proteins influencing mitochondrial transcripts of Trypanosoma brucei

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F12%3A00386346" target="_blank" >RIV/60077344:_____/12:00386346 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/12:00386346 RIV/60076658:12310/12:43883370
Result on the web
<a href="http://dx.doi.org/10.1261/rna.033852.112" target="_blank" >http://dx.doi.org/10.1261/rna.033852.112</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1261/rna.033852.112" target="_blank" >10.1261/rna.033852.112</a>

Result language
angličtina
Original language name
Functional characterization of two paralogs that are novel RNA binding proteins influencing mitochondrial transcripts of Trypanosoma brucei
Original language description
A majority of Trypanosoma brucei proteins have unknown functions, a consequence of its independent evolutionary history within the order Kinetoplastida that allowed for the emergence of several unique biological properties. Among these is RNA editing, needed for expression of mitochondrial-encoded genes. The recently discovered mitochondrial RNA binding complex 1 (MRB1) is composed of proteins with several functions in processing organellar RNA. We characterize two MRB1 subunits, referred to herein as MRB8170 and MRB4160, which are paralogs arisen from a large chromosome duplication occurring only in T. brucei. As with many other MRB1 proteins, both have no recognizable domains, motifs, or orthologs outside the order. We show that they are both novel RNA binding proteins, possibly representing a new class of these proteins. They associate with a similar subset of MRB1 subunits but not directly with each other. We generated cell lines that either individually or simultaneously target th
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
<a href="/en/project/GA204%2F09%2F1667" target="_blank" >GA204/09/1667: Characterization of a novel protein complex involved in RNA processing and editing in the mitochondrion of Trypanosoma brucei</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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