Five functional adipokinetic peptides expressed in the corpus cardiacum of the moth genus Hippotion (Lepidoptera, Sphingidae)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F13%3A00391874" target="_blank" >RIV/60077344:_____/13:00391874 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0167011513000670" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0167011513000670</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.regpep.2013.03.029" target="_blank" >10.1016/j.regpep.2013.03.029</a>

Result language
angličtina
Original language name
Five functional adipokinetic peptides expressed in the corpus cardiacum of the moth genus Hippotion (Lepidoptera, Sphingidae)
Original language description
This is the first study that finds five adipokinetic hormones (AKHs) in the corpus cardiacum of an insect. From two species of the sphingid moth genus Hippotion, eson and celerio, three novel and two known AKHs were isolated and sequenced: Hipes-AKH-I) and its Thr7 analogue (Hipes-AKH-II); two nonapeptides are pGlu-Leu-Thr-Phe-Thr-Ser-Ser-Trp-Gly amide (Manse-AKH) and its Thr7 analogue (Hipes-AKH-III), as well as a decapeptide pGlu-Leu-Thr-Phe-Ser-Ser-Gly-Trp-Gly-Gln amide (Manse-AKH-II). All sequenceswere confirmed by identical behaviour of natural and synthetic peptides in liquid chromatography coupled to electrospray tandem mass spectrometry. Conspecific injections of all five peptides in synthetic form and low doses caused hyperlipaemia in H. eson. Our results suggest that five genes code for the mature peptides, which are very likely released during flight to provide energy for long distance migration in this genus via lipid oximation. As all five peptides are active at low doses
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Project
<a href="/en/project/NT11513" target="_blank" >NT11513: Profiling of neurosteroid conjugates and other acidic metabolites in body fluids and their perspective in clinical diagnostics</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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