Dual core processing: MRB1 is an emerging kinetoplast RNA editing complex

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F13%3A00392769" target="_blank" >RIV/60077344:_____/13:00392769 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/13:43885361
Result on the web
<a href="http://dx.doi.org/10.1016/j.pt.2012.11.005" target="_blank" >http://dx.doi.org/10.1016/j.pt.2012.11.005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.pt.2012.11.005" target="_blank" >10.1016/j.pt.2012.11.005</a>

Result language
angličtina
Original language name
Dual core processing: MRB1 is an emerging kinetoplast RNA editing complex
Original language description
Our understanding of kinetoplastid RNA (kRNA) editing has centered on this paradigm: guide RNAs (gRNAs) provide a blueprint for uridine insertion/deletion into mitochondrial mRNAs by the RNA editing core complex (RECC). The characterization of constituent subunits of the mitochondrial RNA-binding complex 1 (MRB1) implies that it too is vital to the editing process. The recently elucidated MRB1 architecture will be instrumental in putting functional data from individual subunits into context. Our model depicts two functions for MRB1: mediating multi-round kRNA editing by coordinating the exchange of multiple gRNAs required by RECC to edit lengthy regions of mRNAs, and then linking kRNA editing with other RNA processing events.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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