Unexpected role of the steroid-deficiency protein ecdysoneless in pre-mRNA splicing

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F14%3A00427779" target="_blank" >RIV/60077344:_____/14:00427779 - isvavai.cz</a>

Result on the web

<a href="http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1004287" target="_blank" >http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1004287</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pgen.1004287" target="_blank" >10.1371/journal.pgen.1004287</a>

Result language

angličtina

Original language name

Unexpected role of the steroid-deficiency protein ecdysoneless in pre-mRNA splicing

Original language description

This study reveals that the Drosophila ecdysoneless (ecd) gene, known for its mutation causing steroid-hormone deficiency, encodes a novel pre-mRNA splicing factor. Ecd is required for cell survival within proliferating tissues, and simultaneously for pre-mRNA splicing of an essential steroidogenic gene; the latter explains the hormonal deficiency. A human Ecd protein that has been implicated in tumor proliferation can functionally substitute for its Drosophila homolog.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS Genetics

ISSN

1553-7404

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

14

Pages from-to

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UT code for WoS article

000335499600039

EID of the result in the Scopus database

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