Understanding the evolutionary structural variability and target specificity of tick salivary Kunitz peptides using next generation transcriptome data
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F14%3A00430607" target="_blank" >RIV/60077344:_____/14:00430607 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1186/1471-2148-14-4" target="_blank" >http://dx.doi.org/10.1186/1471-2148-14-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/1471-2148-14-4" target="_blank" >10.1186/1471-2148-14-4</a>
Alternative languages
Result language
angličtina
Original language name
Understanding the evolutionary structural variability and target specificity of tick salivary Kunitz peptides using next generation transcriptome data
Original language description
Background: Ticks are blood-sucking arthropods and a primary function of tick salivary proteins is to counteract the host's immune response. Tick salivary Kunitz-domain proteins perform multiple functions within the feeding lesion and have been classified as venoms; thereby, constituting them as one of the important elements in the arms race with the host. The two main mechanisms advocated to explain the functional heterogeneity of tick salivary Kunitz-domain proteins are gene sharing and gene duplication. Both do not, however, elucidate the evolution of the Kunitz family in ticks from a structural dynamic point of view. The Red Queen hypothesis offers a fruitful theoretical framework to give a dynamic explanation for host-parasite interactions. Usingthe recent salivary gland Ixodes ricinus transcriptome we analyze, for the first time, single Kunitz-domain encoding transcripts by means of computational, structural bioinformatics and phylogenetic approaches to improve our understanding
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BMC Evolutionary Biology
ISSN
1471-2148
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
JAN 2014
Country of publishing house
GB - UNITED KINGDOM
Number of pages
16
Pages from-to
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UT code for WoS article
000329966900001
EID of the result in the Scopus database
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