Prediction of Kunitz ion channel effectors and protease inhibitors from the Ixodes ricinus sialome

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F14%3A00435202" target="_blank" >RIV/60077344:_____/14:00435202 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.ttbdis.2014.07.016" target="_blank" >http://dx.doi.org/10.1016/j.ttbdis.2014.07.016</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ttbdis.2014.07.016" target="_blank" >10.1016/j.ttbdis.2014.07.016</a>

Result language

angličtina

Original language name

Prediction of Kunitz ion channel effectors and protease inhibitors from the Ixodes ricinus sialome

Original language description

In the next generation sequencing era we are encountering hundreds of thousands of sequences from specific organisms. Such massive data must be accurately classified both functionally and structurally. Determining appropriate sequences with a specific function from next generation sequencing, however, is a daunting experimental task. A recent salivary gland transcriptome from the hard tick Ixodes ricinus, a European disease vector, has been made publicly available. Among the protein families sequenced by the salivary gland transcriptome of I. ricinus, the Kunitz-domain is one of the highly represented protein families. Thus far, recent tick transciptomes solely classify (computationally) Kunitz sequences as putative serine protease inhibitors. We present here a novel method using a machine-learning algorithm to "fish" for candidate ion-channel effectors and loss of serine protease inhibitor function within the Kunitzdomain protein family of the I. ricinus salivary gland transcriptome.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/EE2.3.30.0032" target="_blank" >EE2.3.30.0032: Promotion of post-doctoral positions in the Biology Centre of the Czech Academy of Sciences aimed to build the global competitiveness of the research teams in the Czech Republic</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Ticks and Tick-borne Diseases

ISSN

1877-959X

e-ISSN

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Volume of the periodical

5

Issue of the periodical within the volume

6

Country of publishing house

DE - GERMANY

Number of pages

4

Pages from-to

947-950

UT code for WoS article

000343385100052

EID of the result in the Scopus database

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