Trypanosome RNA editing: the complexity of getting U in and taking U out

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F16%3A00463393" target="_blank" >RIV/60077344:_____/16:00463393 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/16:43890621

Result on the web

<a href="http://dx.doi.org/10.1002/wrna.1313" target="_blank" >http://dx.doi.org/10.1002/wrna.1313</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/wrna.1313" target="_blank" >10.1002/wrna.1313</a>

Result language

angličtina

Original language name

Trypanosome RNA editing: the complexity of getting U in and taking U out

Original language description

RNA editing, which adds sequence information to RNAs post-transcriptionally, is a widespread phenomenon throughout eukaryotes. The most complex form of this process is the uridine (U) insertion/deletion editing that occurs in the mitochondria of kinetoplastid protists. RNA editing in these flagellates is specified by trans-acting guide RNAs and entails the insertion of hundreds and deletion of dozens of U residues from mitochondrial RNAs to produce mature, translatable mRNAs. An emerging model indicates that the machinery required for trypanosome RNA editing is much more complicated than previously appreciated. A family of RNA editing core complexes (RECCs), which contain the required enzymes and several structural proteins, catalyze cycles of U insertion and deletion. A second, dynamic multiprotein complex, the Mitochondrial RNA Binding 1 (MRB1) complex, has recently come to light as another essential component of the trypanosome RNA editing machinery. MRB1 likely serves as the platform for kinetoplastid RNA editing, and plays critical roles in RNA utilization and editing processivity. MRB1 also appears to act as a hub for coordination of RNA editing with additional mitochondrial RNA processing events. This review highlights the current knowledge regarding the complex molecular machinery involved in trypanosome RNA editing. WIREs RNA 2016, 7:33-51. doi: 10.1002/wrna.1313 For further resources related to this article, please visit the .

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/GA15-21974S" target="_blank" >GA15-21974S: Mitochondrial genome-wide studies of RNA-binding proteins in trypanosomes</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Wiley Interdisciplinary Reviews-RNA

ISSN

1757-7004

e-ISSN

—

Volume of the periodical

7

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

19

Pages from-to

33-51

UT code for WoS article

000369523900003

EID of the result in the Scopus database

2-s2.0-84955723130