Lost in translation: Defects in transfer RNA modifications and neurological disorders
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F17%3A00474108" target="_blank" >RIV/60077344:_____/17:00474108 - isvavai.cz</a>
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422465/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422465/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fnmol.2017.00135" target="_blank" >10.3389/fnmol.2017.00135</a>
Alternative languages
Result language
angličtina
Original language name
Lost in translation: Defects in transfer RNA modifications and neurological disorders
Original language description
Transfer RNAs (tRNAs) are key molecules participating in protein synthesis. To augment their functionality they undergo extensive post-transcriptional modifications and, as such, are subject to regulation at multiple levels including transcription, transcript processing, localization and ribonucleoside base modification. Post-transcriptional enzyme-catalyzed modification of tRNA occurs at a number of base and sugar positions and influences specific anticodon - codon interactions and regulates translation, its efficiency and fidelity. This phenomenon of nucleoside modification is most remarkable and results in a rich structural diversity of tRNA of which over 100 modified nucleosides have been characterized. Most often these hypermodified nucleosides are found in the wobble position of tRNAs, where they play a direct role in codon recognition as well as in maintaining translational efficiency and fidelity, etc. Several recent studies have pointed to a link between defects in tRNA modifications and human diseases including neurological disorders. Therefore, defects in tRNA modifications in humans need intensive characterization at the enzymatic and mechanistic level in order to pave the way to understand how lack of such modifications are associated with neurological disorders with the ultimate goal of gaining insights into therapeutic interventions.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Molecular Neuroscience
ISSN
1662-5099
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
MAY 09
Country of publishing house
CH - SWITZERLAND
Number of pages
8
Pages from-to
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UT code for WoS article
000401424000001
EID of the result in the Scopus database
2-s2.0-85019227688