Extensive flagellar remodeling during the complex life cycle of &ITParatrypanosoma&IT, an early-branching trypanosomatid

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F17%3A00485318" target="_blank" >RIV/60077344:_____/17:00485318 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/17:10365018 RIV/60076658:12310/17:43895724

Result on the web

<a href="http://dx.doi.org/10.1073/pnas.1712311114" target="_blank" >http://dx.doi.org/10.1073/pnas.1712311114</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1073/pnas.1712311114" target="_blank" >10.1073/pnas.1712311114</a>

Result language

angličtina

Original language name

Extensive flagellar remodeling during the complex life cycle of &ITParatrypanosoma&IT, an early-branching trypanosomatid

Original language description

Paratrypanosoma confusum is a monoxenous kinetoplastid flagellate that constitutes the most basal branch of the highly diverse parasitic trypanosomatids, which include human pathogens Trypanosoma and Leishmania. This makes Paratrypanosoma uniquely informative for the evolution of obligatory parasitism from free-living lifestyle and the evolution of human parasitism in some trypanosomatid lineages. It has typical promastigote morphology but also forms surface-attached haptomonads and amastigotes. Haptomonads form by attachment to a surface via a large bulge at the base of the flagellum, which is then remodeled into a thin attachment pad associated with flagellum shortening. Promastigotes and haptomonads multiply by binary division, and the progeny of a haptomonad can either remain attached or grow a flagellum and resume swimming. Whole genome sequencing and transcriptome profiling, in combination with analysis of the cell ultrastructure, reveal how the cell surface and metabolism are adapted to parasitism and how characteristic cytoskeletal features are conserved. Our data demonstrate that surface attachment by the flagellum and the flagellar pocket, a Leishmania-Wke flagellum attachment zone, and a Trypanosoma cruzi-like cytostome are ancestral features, while evolution of extant trypanosomatids, including the human parasites, is associated with genome streamlining and diversification of membrane proteins.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Proceedings of the National Academy of Sciences of the United States of America

ISSN

0027-8424

e-ISSN

—

Volume of the periodical

114

Issue of the periodical within the volume

44

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

11757-11762

UT code for WoS article

000414127400070

EID of the result in the Scopus database

2-s2.0-85032705900