Extensive flagellar remodeling during the complex life cycle of Paratrypanosoma, an early-branching trypanosomatid
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F17%3AA1801ODC" target="_blank" >RIV/61988987:17310/17:A1801ODC - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/17:00100392
Result on the web
<a href="http://dx.doi.org/10.1073/pnas.1712311114" target="_blank" >http://dx.doi.org/10.1073/pnas.1712311114</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1073/pnas.1712311114" target="_blank" >10.1073/pnas.1712311114</a>
Alternative languages
Result language
angličtina
Original language name
Extensive flagellar remodeling during the complex life cycle of Paratrypanosoma, an early-branching trypanosomatid
Original language description
Paratrypanosoma confusum is a monoxenous kinetoplastid flagellate that constitutes the most basal branch of the highly diverse parasitic trypanosomatids, which include human pathogens Trypanosoma and Leishmania. This makes Paratrypanosoma uniquely informative for the evolution of obligatory parasitism from free-living lifestyle and the evolution of human parasitism in some trypanosomatid lineages. It has typical promastigote morphology but also forms surface-attached haptomonads and amastigotes. Haptomonads form by attachment to a surface via a large bulge at the base of the flagellum, which is then remodeled into a thin attachment pad associated with flagellum shortening. Promastigotes and haptomonads multiply by binary division, and the progeny of a haptomonad can either remain attached or grow a flagellum and resume swimming. Whole genome sequencing and transcriptome profiling, in combination with analysis of the cell ultrastructure, reveal how the cell surface and metabolism are adapted to parasitism and how characteristic cytoskeletal features areconserved. Our data demonstrate that surface attachment by the flagellum and the flagellar pocket, a Leishmania -like flagellum attachment zone, and a Trypanosoma cruzi -like cytostome are ancestral features, while evolution of extant trypanosomatids, including the human parasites, is associated with genome streamlining and diversification of membrane proteins.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN
0027-8424
e-ISSN
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Volume of the periodical
114
Issue of the periodical within the volume
44
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
11757-11762
UT code for WoS article
000414127400070
EID of the result in the Scopus database
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