The juvenile hormone receptor as a target of juvenoid “insect growth regulators”
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F20%3A00508376" target="_blank" >RIV/60077344:_____/20:00508376 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/full/10.1002/arch.21615" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1002/arch.21615</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/arch.21615" target="_blank" >10.1002/arch.21615</a>
Alternative languages
Result language
angličtina
Original language name
The juvenile hormone receptor as a target of juvenoid “insect growth regulators”
Original language description
Synthetic compounds that mimic the action of juvenile hormones (JHs) are founding members of a class of insecticides called insect growth regulators (IGRs). Like JHs, these juvenoids block metamorphosis of insect larvae to reproductive adults. Many biologically active juvenoids deviate in their chemical structure considerably from the sesquiterpenoid JHs, raising questions about the mode of action of such JH mimics. Despite the early deployment of juvenoid IGRs in the mid‐1970s, their molecular effect could not be understood until recent discoveries of JH signaling through an intracellular JH receptor, namely the ligand‐binding transcription factor Methoprene‐tolerant (Met). Here, we briefly overview evidence defining three widely employed and chemically distinct juvenoid IGRs (methoprene, pyriproxyfen, and fenoxycarb), as agonist ligands of the JH receptor. We stress that knowledge of the target molecule is critical for using these compounds both as insecticides and as research tools.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Archives of Insect Biochemistry and Physiology
ISSN
0739-4462
e-ISSN
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Volume of the periodical
103
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
e21615
UT code for WoS article
000485949800001
EID of the result in the Scopus database
2-s2.0-85073947451