Epoxidation of juvenile hormone was a key innovation improving insect reproductive fitness
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F21%3A00554391" target="_blank" >RIV/60077344:_____/21:00554391 - isvavai.cz</a>
Result on the web
<a href="https://www.pnas.org/content/118/45/e2109381118" target="_blank" >https://www.pnas.org/content/118/45/e2109381118</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1073/pnas.2109381118" target="_blank" >10.1073/pnas.2109381118</a>
Alternative languages
Result language
angličtina
Original language name
Epoxidation of juvenile hormone was a key innovation improving insect reproductive fitness
Original language description
Methyl farnesoate (MF) plays hormonal regulatory roles in crustaceans. An epoxidated form of MF, known as juvenile hormone (JH), controls metamorphosis and stimulates reproduction in insects. To address the evolutionary significance of MF epoxidation, we generated mosquitoes completely lacking either of the two enzymes that catalyze the last steps of MF/JH biosynthesis and epoxidation, respectively: the JH acid methyltransferase (JHAMT) and the P450 epoxidase CYP15 (EPDX). jhamt(-/-) larvae lacking both MF and JH died at the onset of metamorphosis. Strikingly, epox(-/-) mutants, which synthesized MF but no 1H, completed the entire life cycle. While epox(-/-) adults were fertile, the reproductive performance of both sexes was dramatically reduced. Our results suggest that although MF can substitute for the absence of JH in mosquitoes, it is with a significant fitness cost. We propose that MF can fulfill most roles of JH, but its epoxidation to JH was a key innovation providing insects with a reproductive advantage.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10613 - Zoology
Result continuities
Project
<a href="/en/project/GX20-05151X" target="_blank" >GX20-05151X: Uncovering of missing genetic components and new chemical regulators of juvenile hormone signaling</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424
e-ISSN
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Volume of the periodical
118
Issue of the periodical within the volume
45
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
e2109381118
UT code for WoS article
000720928400015
EID of the result in the Scopus database
2-s2.0-85119276601