A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F22%3A00556963" target="_blank" >RIV/60077344:_____/22:00556963 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/22:00556963 RIV/00027162:_____/22:N0000045 RIV/00216224:14310/22:00125511
Result on the web
<a href="https://doi.org/10.3390/molecules27061894" target="_blank" >https://doi.org/10.3390/molecules27061894</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/molecules27061894" target="_blank" >10.3390/molecules27061894</a>
Alternative languages
Result language
angličtina
Original language name
A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases
Original language description
Positive-sense single-stranded RNA (+RNA) viruses have proven to be important pathogens that are able to threaten and deeply damage modern societies, as illustrated by the ongoing COVID-19 pandemic. Therefore, compounds active against most or many +RNA viruses are urgently needed. Here, we present PR673, a helquat-like compound that is able to inhibit the replication of SARS-CoV-2 and tick-borne encephalitis virus in cell culture. Using in vitro polymerase assays, we demonstrate that PR673 inhibits RNA synthesis by viral RNA-dependent RNA polymerases (RdRps). Our results illustrate that the development of broad-spectrum non-nucleoside inhibitors of RdRps is feasible.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10606 - Microbiology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecules
ISSN
1420-3049
e-ISSN
1420-3049
Volume of the periodical
27
Issue of the periodical within the volume
6
Country of publishing house
CH - SWITZERLAND
Number of pages
10
Pages from-to
1894
UT code for WoS article
000774291500001
EID of the result in the Scopus database
2-s2.0-85126991555