Novel analogues of a nonnucleoside SARS-CoV-2 RdRp inhibitor as potential antivirotics
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F24%3A00586203" target="_blank" >RIV/61388963:_____/24:00586203 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/24:10484033
Result on the web
<a href="https://doi.org/10.3762/bjoc.20.91" target="_blank" >https://doi.org/10.3762/bjoc.20.91</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3762/bjoc.20.91" target="_blank" >10.3762/bjoc.20.91</a>
Alternative languages
Result language
angličtina
Original language name
Novel analogues of a nonnucleoside SARS-CoV-2 RdRp inhibitor as potential antivirotics
Original language description
The RNA-dependent RNA polymerase (RdRp) represents a prominent target in the discovery and development of new antivirotics against RNA viruses, inhibiting the replication process. One of the most targeted RNA viruses of the last years is, without doubt, SARS-CoV-2, the cause of the recent COVID-19 pandemic. HeE1-2Tyr, a known inhibitor of flaviviral RdRp, has been discovered to also have antiviral potency against this coronavirus. In this study, we report three distinct modifications of HeE1-2Tyr: conversion of the core from a benzothiazole to a benzoxazole moiety and two different scaffold simplifications, respectively. We provide a novel synthetic approach and, in addition, evaluate the final molecules in an in vitro polymerase assay for biological activity.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Beilstein Journal of Organic Chemistry
ISSN
1860-5397
e-ISSN
1860-5397
Volume of the periodical
20
Issue of the periodical within the volume
May
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
1029-1036
UT code for WoS article
001221029600001
EID of the result in the Scopus database
2-s2.0-85193861096