Advances in vertebrate (cyto)genomics shed new light on fish compositional genome evolution

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00583820" target="_blank" >RIV/60077344:_____/23:00583820 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/23:43906428 RIV/62690094:18450/23:50020270 RIV/62690094:18470/23:50020270

Result on the web

<a href="https://doi.org/10.3390/genes14020244" target="_blank" >https://doi.org/10.3390/genes14020244</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/genes14020244" target="_blank" >10.3390/genes14020244</a>

Result language

angličtina

Original language name

Advances in vertebrate (cyto)genomics shed new light on fish compositional genome evolution

Original language description

Cytogenetic and compositional studies considered fish genomes rather poor in guanine-cytosine content (GC%) because of a putative 'sharp increase in genic GC% during the evolution of higher vertebrates'. However, the available genomic data have not been exploited to confirm this viewpoint. In contrast, further misunderstandings in GC%, mostly of fish genomes, originated from a misapprehension of the current flood of data. Utilizing public databases, we calculated the GC% in animal genomes of three different, technically well-established fractions: DNA (entire genome), cDNA (complementary DNA), and cds (exons). Our results across chordates help set borders of GC% values that are still incorrect in literature and show: (i) fish in their immense diversity possess comparably GC-rich (or even GC-richer) genomes as higher vertebrates, and fish exons are GC-enriched among vertebrates., (ii) animal genomes generally show a GC-enrichment from the DNA, over cDNA, to the cds level (i.e., not only the higher vertebrates)., (iii) fish and invertebrates show a broad(er) inter-quartile range in GC%, while avian and mammalian genomes are more constrained in their GC%. These results indicate no sharp increase in the GC% of genes during the transition to higher vertebrates, as stated and numerously repeated before. We present our results in 2D and 3D space to explore the compositional genome landscape and prepared an online platform to explore the AT/GC compositional genome evolution.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10620 - Other biological topics

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Genes

ISSN

2073-4425

e-ISSN

2073-4425

Volume of the periodical

14

Issue of the periodical within the volume

2

Country of publishing house

CH - SWITZERLAND

Number of pages

16

Pages from-to

244

UT code for WoS article

000939064500001

EID of the result in the Scopus database

2-s2.0-85148873460