Juvenile hormones direct primordial germ cell migration to the embryonic gonad
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F24%3A00584656" target="_blank" >RIV/60077344:_____/24:00584656 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.cub.2023.12.033" target="_blank" >https://doi.org/10.1016/j.cub.2023.12.033</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cub.2023.12.033" target="_blank" >10.1016/j.cub.2023.12.033</a>
Alternative languages
Result language
angličtina
Original language name
Juvenile hormones direct primordial germ cell migration to the embryonic gonad
Original language description
Germ cells are essential to sexual reproduction. Across the animal kingdom, extracellular signaling isoprenoids, such as retinoic acids (RAs) in vertebrates and juvenile hormones (JHs) in invertebrates, facilitate multiple processes in reproduction. Here we investigated the role of these potent signaling molecules in embryonic germ cell development, using JHs in Drosophila melanogaster as a model system. In contrast to their established endocrine roles during larval and adult germline development, we found that JH signaling acts locally during embryonic development. Using an in vivo biosensor, we observed active JH signaling first within and near primordial germ cells (PGCs) as they migrate to the developing gonad. Through in vivo and in vitro assays, we determined that JHs are both necessary and sufficient for PGC migration. Analysis into the mechanisms of this newly uncovered paracrine JH function revealed that PGC migration was compromised when JHs were decreased or increased, suggesting that specific titers or spatiotemporal JH dynamics are required for robust PGC colonization of the gonad. Compromised PGC migration can impair fertility and cause germ cell tumors in many species, including humans. In mammals, retinoids have many roles in development and reproduction. We found that like JHs in Drosophila, RA was sufficient to impact mouse PGC migration in vitro. Together, our study reveals a previously unanticipated role of isoprenoids as local effectors of pregonadal PGC development and suggests a broadly shared mechanism in PGC migration.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GA22-21244S" target="_blank" >GA22-21244S: Deciphering juvenile hormone (JH) dependent regulation of development and reproduction in mosquitoes using JH null mutants</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Biology
ISSN
0960-9822
e-ISSN
1879-0445
Volume of the periodical
34
Issue of the periodical within the volume
FEB 5 2024
Country of publishing house
US - UNITED STATES
Number of pages
21
Pages from-to
č. 3
UT code for WoS article
001181652400001
EID of the result in the Scopus database
2-s2.0-85183020212