Role of Aralkylamine N‐Acetyltransferase in the Response to Antioxidative Stress in the Fruit Fly Drosophila Melanogaster Adults
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F24%3A00601765" target="_blank" >RIV/60077344:_____/24:00601765 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/24:43908474 RIV/60076658:12520/24:43908474
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1002/arch.70009" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1002/arch.70009</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/arch.70009" target="_blank" >10.1002/arch.70009</a>
Alternative languages
Result language
angličtina
Original language name
Role of Aralkylamine N‐Acetyltransferase in the Response to Antioxidative Stress in the Fruit Fly Drosophila Melanogaster Adults
Original language description
In multicellular organisms, the indole melatonin synthesized by aralkylamine N‐acetyltransferase (AANATI) serves as an antioxidant. To test this, sex‐mixed 3‐day‐old mated fly adults bw1 and AANAT1 homozygous recessive loss‐of‐function mutant (bw AANAT1lo) of Drosophila melanogaster were fed by a standard diet or by one containing paraquat (PQ, 1,1′‐dimethyl‐4,4′‐bipyridilium dichloride hydrate) at a final concentration of 15.5 mM. Experiment lasted 8 h and began at 11 a.m. In bw1 flies the paraquat treatment resulted in a significant (evaluated by Student's t‐tests) decrease of the superoxide dismutase (SOD) activity and an increase the catalase (CAT) and glutathione S‐transferase (GST) activities. Meanwhile, in these flies, total Antioxidative capacity (TAC) was significantly curbed by the paraquat presence. Importantly, these changes were not observed in the AANAT1‐mutants. Thus, melatonin seems to play an important defence role against the oxidative stress elicited by paraquat.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10605 - Developmental biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Archives of Insect Biochemistry and Physiology
ISSN
0739-4462
e-ISSN
1520-6327
Volume of the periodical
117
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
e70009
UT code for WoS article
001370235600001
EID of the result in the Scopus database
2-s2.0-85210085627