The Asgard archaeal origins of Arf family GTPases involved in eukaryotic organelle dynamics
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F25%3A00617106" target="_blank" >RIV/60077344:_____/25:00617106 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17310/25:A26039VC
Result on the web
<a href="https://doi.org/10.1038/s41564-024-01904-6" target="_blank" >https://doi.org/10.1038/s41564-024-01904-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41564-024-01904-6" target="_blank" >10.1038/s41564-024-01904-6</a>
Alternative languages
Result language
angličtina
Original language name
The Asgard archaeal origins of Arf family GTPases involved in eukaryotic organelle dynamics
Original language description
The evolution of eukaryotes is a fundamental event in the history of life. The closest prokaryotic lineage to eukaryotes, the Asgardarchaeota, encode proteins previously found only in eukaryotes, providing insight into their archaeal ancestor. Eukaryotic cells are characterized by endomembrane organelles, and the Arf family GTPases regulate organelle dynamics by recruiting effector proteins to membranes upon activation. The Arf family is ubiquitous among eukaryotes, but its origins remain elusive. Here we report a group of prokaryotic GTPases, the ArfRs, which are widely present in Asgardarchaeota. Phylogenetic analyses reveal that eukaryotic Arf family proteins arose from the ArfR group. Expression of representative Asgardarchaeota ArfR proteins in yeast and X-ray crystallographic studies show that ArfR GTPases possess the mechanism of membrane binding and structural features unique to Arf family proteins. Our results indicate that Arf family GTPases originated in the archaeal ancestor of eukaryotes, consistent with aspects of the endomembrane system evolving early in eukaryogenesis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Microbiology
ISSN
2058-5276
e-ISSN
2058-5276
Volume of the periodical
10
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
495-508
UT code for WoS article
001403307400001
EID of the result in the Scopus database
2-s2.0-85217231692