Therapeutic induction of programmed cell death

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG16__%2F00%3A00000472" target="_blank" >RIV/60162694:G16__/00:00000472 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Therapeutic induction of programmed cell death
Original language description
Cells and multicellular organisms share the ability to activate an internal death program known as apoptosis. Apoptosis theory, developed over the last 20 years, has challenged conceptual thinking in all aspects of cell biology. In cancer, the increase in the tumor burden can be regarded as the result of too much growth and too little death of the tumor cells. Therefore, the aim of chemotherapy and radiotherapy is to block proliferation and to enhance cell death. One of the major signaling pathways initiated by DNA damage and other cytotoxic stresses involves the induction of TP53 protein. Via induction of TP53, DNA damage can induce growth arrest or programmed cell death in many cell types. This induction response appears to be a major determinant ofresponses to chemotherapy in certain tumor types, such as those derived from lymphoid cells or germ cells. Mutation or loss of TP53 genes in hematopoietic malignancies appears to correlate well with poor prognosis. The mitochondria play k
Czech name
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Czech description
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Publication year
2000
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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