Induction and characterization of a replication competent cervid endogenous gammaretrovirus (CrERV) from mule deer cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG33__%2F15%3AN0000002" target="_blank" >RIV/60162694:G33__/15:N0000002 - isvavai.cz</a>

Alternative codes found

RIV/68378050:_____/15:00455200

Result on the web

<a href="http://hdl.handle.net/11104/0255872" target="_blank" >http://hdl.handle.net/11104/0255872</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Induction and characterization of a replication competent cervid endogenous gammaretrovirus (CrERV) from mule deer cells

Original language description

Endogenous retroviruses (ERVs) were acquired during evolution of their host organisms after infection and mendelian inheritance in the germline by their exogenous counterparts. The ERVs can spread in the host genome and in some cases they affect the host phenotype. The cervid endogenous gammaretrovirus (CrERV) is one of only a few well-defined examples of evolutionarily recent invasion of mammalian genome by retroviruses. Thousands of insertionally polymorphic CrERV integration sites have been detected in wild ranging mule deer (Odocoileus hemionus) host populations. Here, we describe for the first time induction of replication competent CrERV by cocultivation of deer and human cells. We characterize the physical properties and tropism of the induced virus. The genomic sequence of the induced virus is phylogenetically related to the evolutionarily young endogenous CrERVs described so far. We also describe the level of replication block of CrERV on deer cells and its capacity to establish superinfection interference. (C) 2015 Elsevier Inc. All rights reserved.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/LK11215" target="_blank" >LK11215: Regulation of active endogenous retroviruses in the mammalian genome</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Virology

ISSN

0042-6822

e-ISSN

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Volume of the periodical

485

Issue of the periodical within the volume

November

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

96-103

UT code for WoS article

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EID of the result in the Scopus database

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