Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium-oximes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG38__%2F04%3A00001080" target="_blank" >RIV/60162694:G38__/04:00001080 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium-oximes
Original language description
Cyclohexyl methylphosphonofluoridate (cyclosarin, cyclosin, GF) is a highly toxic organophosphate, which was resistant to conventional oxime therapy. To give more insight into the reactivation kinetics, rat brain acetylcholinesterase (AChE) was inhibitedin vitro by cyclosarin (pH 8.0, 25 °C) and reactivated with 22 different pyridinium-oximes. Only three compounds were shown to be superior to the other oximes: 4-carbamoyl-4´-[(hydroxyimino)methyl]-1,1´-(oxydimethylene)dipyridin-1-ium dichloride (HS-6),4´-carbamoyl-2-[(hydroxyimino)methyl]-1,1´-(oxydimethylene)dipyridin-1-ium dichloride (HI-6), and 4´-carbamoyl-2-[(hydroxyimino)methyl]-1,1´-(but-2-ene-1,4-diyl)dipyridin-1-ium dichloride (BI-6).
Czech name
Reaktivace cyklosarinem inhibované acetylcholinesterázy pyridiniovými oximy
Czech description
Reaktivace cyklosarinem inhibované acetylcholinesterázy pyridiniovými oximy

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
—

Project
<a href="/en/project/ONVLAJEP20031" target="_blank" >ONVLAJEP20031: New possibilities of therapy of cyclosin intoxication: Synthesis and testing of new acethylcholinesterase reactivators</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)