Prediction of a new broad-spectrum reactivator capable to reactivate acetylcholinesterase inhibited by nerve agents

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F05%3A00001250" target="_blank" >RIV/60162694:G44__/05:00001250 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Prediction of a new broad-spectrum reactivator capable to reactivate acetylcholinesterase inhibited by nerve agents
Original language description
The methodology combining molecular structure representing by fragments and artificial neural network (ANN) was applied for the prediction of new acetylcholinesterase (AChE; EC 3.1.1.7) reactivator. We have searched for new AChE reactivator's structure with capability for reactivation of AChE inhibited by almost all actual nerve agents. For this purpose, we have tested in vitro seventeen potential AChE reactivators for reactivation of AChE inhibited by sarin, cyclosarin, agent VX and tabun. Afterwards,obtained results were used as input data for prediction by ANN. Using ANN we have predicted new AChE reactivators.
Czech name
Predikce nového širokospektrálního reaktivátoru schopného reaktivovat AChE inhibovanou NPL
Czech description
Predikce nového širokospektrálního reaktivátoru schopného reaktivovat AChE inhibovanou NPL.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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