Relationship between structure of chlorpyrifos-inhibited acetylcholinesterase reactivators and their biological activity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F07%3A00001813" target="_blank" >RIV/60162694:G44__/07:00001813 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Relationship between structure of chlorpyrifos-inhibited acetylcholinesterase reactivators and their biological activity

Original language description

Parathion, chlorpyrifos, and malathion are organophosphorus substances used as pesticides in agriculture. Due to the volume of their worldwide use, they are commonly encountered substances. These compounds inhibit the enzyme acetylcholinesterase (AChE; EC 3.1.1.7) via phosphorylation of its active site. AChE reactivators and anticholinergics are compounds used as antidotes in the case of intoxication with these agents. Chlorpyrifos, a representative member of this pesticide family, was used to inhibit the AChE activity of rat brain. In this work, the reactivation activity of twenty-one structurally different AChE reactivators was tested in vitro and subsequently, the relationship between their chemical structure and biological activity was outlined.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

<a href="/en/project/ME%20865" target="_blank" >ME 865: Countermeasure against chemical terrorism - development of new antidotes against nerve agents</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemical Papers-Chemicke Zvesti

ISSN

0366-6352

e-ISSN

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Volume of the periodical

61

Issue of the periodical within the volume

4

Country of publishing house

PL - POLAND

Number of pages

6

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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