Synthesis, antidotal effects and HPLC behavior of some novel pyridinium aldoximes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F10%3A00002296" target="_blank" >RIV/60162694:G44__/10:00002296 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Synthesis, antidotal effects and HPLC behavior of some novel pyridinium aldoximes

Original language description

Pyridinium aldoximes are used as antidotes in organophosphate poisoning. In the reactivation process they form a complex with the organophosphates, even the serine active site of acetyl-cholinesterase enzymes had been inactivated by the organophosphorouscompounds. Essential disadvantage of the recently used pyridinium aldoximes is the instability and the toxicity of these complexes. Novel pyridinium aldoximes show more effective detoxifying effects. A general scheme of the synthesis of several novel and very promising pyridinium aldoximes and their basic characteristics are shown in this paper.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Current Organic Chemistry

ISSN

1385-2728

e-ISSN

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Volume of the periodical

14

Issue of the periodical within the volume

5

Country of publishing house

AE - UNITED ARAB EMIRATES

Number of pages

10

Pages from-to

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UT code for WoS article

000274423600003

EID of the result in the Scopus database

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