Dynamics of apoptosis in gamma-irradiated lymphocytes and the CD21(+)CD27(+) B-cell subset as a potential biodosimetric marker

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F11%3A00002454" target="_blank" >RIV/60162694:G44__/11:00002454 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.radmeas.2011.04.005" target="_blank" >http://dx.doi.org/10.1016/j.radmeas.2011.04.005</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Dynamics of apoptosis in gamma-irradiated lymphocytes and the CD21(+)CD27(+) B-cell subset as a potential biodosimetric marker

Original language description

The dynamics of apoptosis progression has been studied in human peripheral blood mononuclear cells (PBMC) irradiated with selected doses (0.5, 1, 2, 4, 6, 8 and 10 Gy) of 60Co gamma rays and subsequently cultivated for 16 h in vitro. A dose-dependent increase and decrease of shrunk and intact cells, respectively, has been observed in the range of 0.5-4 Gy while higher doses have not affected the relative numbers of intact and apoptotic cells. The relative number of early apoptotic cells did not change within the dose range studied. Immunophenotyping of intact and very early apoptotic cells have indicated that the remaining intact cells represent the most convenient population for radioresistance studies in vitro. The CD21(+)CD27(+) subset of peripheralB-cells has thus been suggested as a putative biodosimetric marker in vitro.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Radiation Measurements

ISSN

1350-4487

e-ISSN

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Volume of the periodical

46

Issue of the periodical within the volume

9

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

1009-1013

UT code for WoS article

000296039300055

EID of the result in the Scopus database

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