Method of static diffusion cells for assesssment of pesticides skin permeation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F11%3A00002478" target="_blank" >RIV/60162694:G44__/11:00002478 - isvavai.cz</a>
Result on the web
<a href="http://www.vojenskaskola.cz/school/ud/fmhs/research_development/Documents/MMSL_2011_2_1_WWW.pdf" target="_blank" >http://www.vojenskaskola.cz/school/ud/fmhs/research_development/Documents/MMSL_2011_2_1_WWW.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Method of static diffusion cells for assesssment of pesticides skin permeation
Original language description
Usage and misusage of pesticides represent a health risk to military and civilian, especially to agricultural workers; also a possible terrorist threat is considered. The major route of low-volatility pesticides intoxication is percutaneous. Hence, skinpermeation characteristics of pesticides are intensively investigated. In this study, in vitro measurement of skin permeation is presented on the example of pesticide paraoxon. Permeation experiments were performed in Franz-type of static diffusion cellsusing a pig skin. Paraoxon which permeated through the skin was determined enzymatically by modified Ellman's method. During 8 hours experiment, approx. 0.1 % of applied paraoxon has permeated through the skin. It was shown that pre-treatment by water simulating wet or sweated skin enhanced the paraoxon permeation.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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