In vitro skin permeation and decontamination of the organophosphorus pesticide paraoxon under various physical conditions : evidence for a wash-in effect
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F12%3A43874671" target="_blank" >RIV/60162694:G44__/12:43874671 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3109/15376516.2012.686535" target="_blank" >http://dx.doi.org/10.3109/15376516.2012.686535</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/15376516.2012.686535" target="_blank" >10.3109/15376516.2012.686535</a>
Alternative languages
Result language
čeština
Original language name
In vitro skin permeation and decontamination of the organophosphorus pesticide paraoxon under various physical conditions : evidence for a wash-in effect
Original language description
Misuse of various chemicals, such as chemical warfare agents, industrial chemicals or pesticides during warfare or terrorists attacks requires adequate protection. Thus, development and evaluation of novel decontamination dispositives and techniques areneeded. In this study, in vitro permeation and decontamination of a potentially hazardous compound paraoxon, an active metabolite of organophosphorus pesticide parathion, was investigated. Skin permeation and decontamination experiments were carried outin modified Franz diffusion cells. Pig skin was used as a human skin model. Commercially produced detergent-based washing solutions FloraFreeTM and ArgosTM were used as decontamination means. The experiments were done under "warm", "cold", "dry" and "wet" skin conditions in order to determine an effect of various physical conditions on skin permeation of paraoxon and on a subsequent decontamination process. There was no significant difference in skin permeation of paraoxon under warm, co
Czech name
In vitro skin permeation and decontamination of the organophosphorus pesticide paraoxon under various physical conditions : evidence for a wash-in effect
Czech description
Misuse of various chemicals, such as chemical warfare agents, industrial chemicals or pesticides during warfare or terrorists attacks requires adequate protection. Thus, development and evaluation of novel decontamination dispositives and techniques areneeded. In this study, in vitro permeation and decontamination of a potentially hazardous compound paraoxon, an active metabolite of organophosphorus pesticide parathion, was investigated. Skin permeation and decontamination experiments were carried outin modified Franz diffusion cells. Pig skin was used as a human skin model. Commercially produced detergent-based washing solutions FloraFreeTM and ArgosTM were used as decontamination means. The experiments were done under "warm", "cold", "dry" and "wet" skin conditions in order to determine an effect of various physical conditions on skin permeation of paraoxon and on a subsequent decontamination process. There was no significant difference in skin permeation of paraoxon under warm, co
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/OVUOFVZ200803" target="_blank" >OVUOFVZ200803: Development of novel decontaminants and disinfectants of skin based on micellar compounds</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Toxicology Mechanisms and Methods
ISSN
1537-6516
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
7
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
520-525
UT code for WoS article
000307997700004
EID of the result in the Scopus database
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