Metrifonate alters antioxidant levels and caspase activity in cerebral cortex of Wistar rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F11%3A00002511" target="_blank" >RIV/60162694:G44__/11:00002511 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3109/15376516.2011.589089" target="_blank" >http://dx.doi.org/10.3109/15376516.2011.589089</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Metrifonate alters antioxidant levels and caspase activity in cerebral cortex of Wistar rats
Original language description
Metrifonate (trichlorfon) is an inhibitor of acetylcholinesterase (AChE). It was used as an Alzheimer's disease (AD) drug; however, the application was withdrawn due to adverse effects. Implication of metrifonate for the antioxidant status and regulationof apoptotic processes was evaluated in the present study. Wistar rats (six per group) were exposed subcutaneously to either 60 or 120 mg/kg of body weight of metrifonate and compared with the controls treated with saline only. Cerebral cortex and livertissues were collected from animals 40 min after exposure. Activities of AChE, glutathione reductase, glutathione-S-transferase, caspase 3, total protein level, thiobarbituric acid reactive substances, reduced glutathione level and ferric reducing antioxidant power (FRAP) were assayed in the tissue samples. Metrifonate had only lower impact on oxidative stress in the liver. Cerebral cortex tissues had decreased AChE and increased caspase 3 activities as well as the FRAP level. Owing to
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EA - Morphology and cytology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/OVUOFVZ200905" target="_blank" >OVUOFVZ200905: Influence of the nerve agent and reactivators of Acetyl Choline Esterase on the Guinea Pig</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Toxicology Mechanisms and Methods
ISSN
1537-6524
e-ISSN
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Volume of the periodical
21
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
585-590
UT code for WoS article
000295177300004
EID of the result in the Scopus database
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