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Metrifonate alters antioxidant levels and caspase activity in cerebral cortex of Wistar rats

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F11%3A00002511" target="_blank" >RIV/60162694:G44__/11:00002511 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.3109/15376516.2011.589089" target="_blank" >http://dx.doi.org/10.3109/15376516.2011.589089</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Metrifonate alters antioxidant levels and caspase activity in cerebral cortex of Wistar rats

  • Original language description

    Metrifonate (trichlorfon) is an inhibitor of acetylcholinesterase (AChE). It was used as an Alzheimer's disease (AD) drug; however, the application was withdrawn due to adverse effects. Implication of metrifonate for the antioxidant status and regulationof apoptotic processes was evaluated in the present study. Wistar rats (six per group) were exposed subcutaneously to either 60 or 120 mg/kg of body weight of metrifonate and compared with the controls treated with saline only. Cerebral cortex and livertissues were collected from animals 40 min after exposure. Activities of AChE, glutathione reductase, glutathione-S-transferase, caspase 3, total protein level, thiobarbituric acid reactive substances, reduced glutathione level and ferric reducing antioxidant power (FRAP) were assayed in the tissue samples. Metrifonate had only lower impact on oxidative stress in the liver. Cerebral cortex tissues had decreased AChE and increased caspase 3 activities as well as the FRAP level. Owing to

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EA - Morphology and cytology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/OVUOFVZ200905" target="_blank" >OVUOFVZ200905: Influence of the nerve agent and reactivators of Acetyl Choline Esterase on the Guinea Pig</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Toxicology Mechanisms and Methods

  • ISSN

    1537-6524

  • e-ISSN

  • Volume of the periodical

    21

  • Issue of the periodical within the volume

    8

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    6

  • Pages from-to

    585-590

  • UT code for WoS article

    000295177300004

  • EID of the result in the Scopus database