Metrifonate alters antioxidant levels and caspase activity in cerebral cortex of Wistar rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F11%3A43870601" target="_blank" >RIV/62157124:16170/11:43870601 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/11:10104922
Result on the web
<a href="http://dx.doi.org/10.3109/15376516.2011.589089" target="_blank" >http://dx.doi.org/10.3109/15376516.2011.589089</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/15376516.2011.589089" target="_blank" >10.3109/15376516.2011.589089</a>
Alternative languages
Result language
angličtina
Original language name
Metrifonate alters antioxidant levels and caspase activity in cerebral cortex of Wistar rats
Original language description
Metrifonate (trichlorfon) is an inhibitor of acetylcholinesterase (AChE). It was used as an Alzheimer's disease (AD) drug; however, the application was withdrawn due to adverse effects. Implication of metrifonate for the antioxidant status and regulationof apoptotic processes was evaluated in the present study. Wistar rats (six per group) were exposé subcutaneously to either 60 or 120 mg/kg of body weight of metrifonate and compared with the controls treated with saline only. Cerebral cortex and livertissues were collected from animals 40 min after exposure. Activities of AChE, glutathione reductase, glutathione-S-transferase, caspase 3, total protein level, thiobarbituric acid reactive substances, reduced glutathione level and ferric reducing antioxidant power (FRAP) were assayed in the tissue samples. Metrifonate had only lower impact on oxidative stress in the liver. Cerebral cortex tissues had decreased AChE and increased caspase 3 activities as well as the FRAP level. Owing to t
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Toxicology Mechanisms and Methods
ISSN
1537-6516
e-ISSN
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Volume of the periodical
21
Issue of the periodical within the volume
8
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
"585?590"
UT code for WoS article
000295177300004
EID of the result in the Scopus database
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