Specific antibodies protect gamma-irradiated mice against Francisella tularensis infection

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F12%3A43873094" target="_blank" >RIV/60162694:G44__/12:43873094 - isvavai.cz</a>
Result on the web
<a href="http://ac.els-cdn.com/S0882401012001386/1-s2.0-S0882401012001386-main.pdf?_tid=8a6eae34-9780-11e2-b03e-00000aacb35e&acdnat=1364459090_410a27b7d29bef3f917b618f15380b4a" target="_blank" >http://ac.els-cdn.com/S0882401012001386/1-s2.0-S0882401012001386-main.pdf?_tid=8a6eae34-9780-11e2-b03e-00000aacb35e&acdnat=1364459090_410a27b7d29bef3f917b618f15380b4a</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.micpath.2012.07.006" target="_blank" >10.1016/j.micpath.2012.07.006</a>

Result language
angličtina
Original language name
Specific antibodies protect gamma-irradiated mice against Francisella tularensis infection
Original language description
The role of antibodies in the course of Francisella tularensis infection is still a subject of debate. In this study, we demonstrate that passive transfer of immune sera protected irradiated mice against subsequent infection with attenuated as well as virulent strains of F. tularensis subsp. holarctica. Na?ve mice of BALB/c or C3H/CBi strains were subjected to passive transfer of sera obtained from immunized mice with live F. tularensis LVS, F. tularensis subsp. holarctica strain 15, heat-killed F. tularensis LVS, or heat killed strain 15 two hours before infection with lethal doses of LVS or strain 15. The passive transfer of sera obtained from immunized mice conferred full protection of na?ve unirradiated as well as sublethally irradiated mice against low lethal doses of infection with F. tularensis LVS or strain 15, in all variants of the experiments. Moreover, the passively protected mice that survived the primary infection with F. tularensis LVS were protected also against further
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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