Proteomic methods of detection and quantification of protein toxins

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F18%3A43889540" target="_blank" >RIV/60162694:G44__/18:43889540 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G33__/18:N0000001
Result on the web
<a href="http://www.mdpi.com/2072-6651/10/3/99/htm" target="_blank" >http://www.mdpi.com/2072-6651/10/3/99/htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/toxins10030099" target="_blank" >10.3390/toxins10030099</a>

Result language
angličtina
Original language name
Proteomic methods of detection and quantification of protein toxins
Original language description
Biological toxins are a heterogeneous group of compounds that share commonalities with biological and chemical agents. Among them, protein toxins represent a considerable, diverse set. They cover a broad range of molecular weights from less than 1000 Da to more than 150 kDa. This review aims to compare conventional detection methods of protein toxins such as in vitro bioassays with proteomic methods, including immunoassays and mass spectrometry-based techniques and their combination. Special emphasis is given to toxins falling into a group of selected agents, according to the Centers for Disease Control and Prevention, such as Staphylococcal enterotoxins, Bacillus anthracis toxins, Clostridium botulinum toxins, Clostridium perfringens epsilon toxin, ricin from Ricinus communis, Abrin from Abrus precatorius or control of trade in dual-use items in the European Union, including lesser known protein toxins such as Viscumin from Viscum album. The analysis of protein toxins and monitoring for biological threats, i.e., the deliberate spread of infectious microorganisms or toxins through water, food, or the air, requires rapid and reliable methods for the early identification of these agents.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30108 - Toxicology

Project
<a href="/en/project/VH20172020012" target="_blank" >VH20172020012: Preparation of the collection of biologically significant toxins with the support of European biological European biodefence laboratory network</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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