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Some Possibilities to Study New Prophylactics against Nerve Agents

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F19%3A00536991" target="_blank" >RIV/60162694:G44__/19:00536991 - isvavai.cz</a>

  • Alternative codes found

    RIV/62690094:18470/19:50015708 RIV/00179906:_____/19:10400262

  • Result on the web

    <a href="http://www.eurekaselect.com/170345/article" target="_blank" >http://www.eurekaselect.com/170345/article</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2174/1389557519666190301112530" target="_blank" >10.2174/1389557519666190301112530</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Some Possibilities to Study New Prophylactics against Nerve Agents

  • Original language description

    Nerve agents belong to the most dangerous chemical warfare agents and can be/were misused by terrorists. Effective prophylaxis and treatment is necessary to diminish their effect. General principles of prophylaxis are summarized (protection against acetylcholinesterase inhibition, detoxification, treatment "in advance" and use of different drugs). They are based on the knowledge of mechanism of action of nerve agents. Among different examinations, it is necessary to test prophylactic effectivity in vivo and compare the results with protection in vitro. Chemical and biological approaches to the development of new prophylactics would be applied simultaneously during this research. Though the number of possible prophylactics is relatively high, the only four drugs were introduced into military medical practice. At present, pyridostigmine seems to be common prophylactic antidote; prophylactics panpal (tablets with pyridostigmine, trihexyphenidyl and benactyzine), transant (transdermal patch containing HI-6) are other means introduced into different armies as prophylactics. Scavenger commercionally available is Protexia (R). Future development will be focused on scavengers, and on other drugs either reversible cholinesterase inhibitors (e.g., huperzine A, gallantamine, physostigmine, acridine derivatives) or other compounds.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30107 - Medicinal chemistry

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Mini-Reviews in Medicinal Chemistry

  • ISSN

    1389-5575

  • e-ISSN

    1875-5607

  • Volume of the periodical

    19

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    AE - UNITED ARAB EMIRATES

  • Number of pages

    10

  • Pages from-to

    970-979

  • UT code for WoS article

    000475297900003

  • EID of the result in the Scopus database

    2-s2.0-85070662184