Prophylaxis against nerve agents
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F09%3A00002123" target="_blank" >RIV/60162694:G44__/09:00002123 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Prophylaxis against nerve agents
Original language description
Prophylaxis against nerve agent intoxication is based on various approaches: keeping acetylcholinesterase intact (protection of cholinesterases) is a basic requirement for effective prophylaxis. The use of pyridostigmine alone or pyridostigmine with benactyzine and trihehyphenidyle (PANPAL) is typical example. Detoxification realised by administration of the enzymes splitting the organophosphate or evaluating specific enzymes (cholinesterases) is another possibility (stoichiometric and catalytic scavengers). Equine butyrylcholinesterase is an example of stoichiometric scavenger. The antidotes currently used for the treatment of organophosphate poisoning including reactivators are to be tested as prophylactics. As a result of this research, prophylacticantidote TRANSANT (transdermal patch containing HI-6) was developed as the prophylactic mean and introduced into the Czech Armed Forces.
Czech name
—
Czech description
—
Classification
Type
C - Chapter in a specialist book
CEP classification
FP - Other medical fields
OECD FORD branch
—
Result continuities
Project
—
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Central and peripheral nervous system: effects of highly toxic organophosphates and their antidotes
ISBN
978-81-308-0331-9
Number of pages of the result
12
Pages from-to
—
Number of pages of the book
151
Publisher name
Research Signpost
Place of publication
Kerala
UT code for WoS chapter
—